Article
High-resolution X-ray study of deoxyhemoglobin Rothschild 37 beta Trp----Arg: a mutation that creates an intersubunit chloride-binding site.
Biochemistry - 28 Apr 1992
Kavanaugh J S, Rogers P H, Case D A, Arnone A
Abstract excerpt
The mutation site in hemoglobin Rothschild (37 beta Trp----Arg) is located in the "hinge region" of the alpha 1 beta 2 interface, a region that is critical for normal hemoglobin function. The mutation results in greatly reduced cooperativity and an oxygen affinity similar to that of hemoglobin A...
Topics
- Anions
- Binding Sites
- Chemical Phenomena
- Chemistry, Physical
- Chlorides
- Crystallization
- Hemoglobins
- Hemoglobins, Abnormal
- Humans
- Hydrogen Bonding
- Macromolecular Substances
- Molecular Structure
- Mutation
- Protein Conformation
- X-Ray Diffraction