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Article

Chloride ion independence of the Bohr effect in a mutant human hemoglobin beta (V1M+H2deleted).

The Journal of biological chemistry - 30 Sept 1994

Fronticelli C, Pechik I, Brinigar W S, Kowalczyk J, Gilliland G L

Abstract excerpt

A mutant human hemoglobin, beta (V1M+H2 delta), has been constructed. Analysis of the oxygen binding curves obtained at pH 8.3, where the Bohr effect is inoperative, indicates that this mutation results in an additional stabilization of the T-state conformation by 0.9 kcal/mol. The crystal structure of deoxy-beta (V1M+H2 delta) has been determined to 2.2-A resolution and compared with the deoxy structure of human...

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PMID: 7929044

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