Article
The N-terminal sequence affects distant helix interactions in hemoglobin. Implications for mutant proteins from studies on recombinant hemoglobin felix.
The Journal of biological chemistry - 25 Dec 1998
Dumoulin A, Padovan J C, Manning L R, Popowicz A, Winslow R M, Chait B T, Manning J M
Abstract excerpt
The N-terminal 18-amino acid sequence of the beta-chain of hemoglobin, as far as the end of the A helix, has been replaced by the corresponding sequence of the gamma-chain of fetal hemoglobin with the remaining sequence of the beta-chain retained (helices B through H). The gamma-beta-chain had th...
Topics
- Amino Acid Sequence
- Circular Dichroism
- Fetal Hemoglobin
- Hemoglobin A
- Mass Spectrometry
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Protein Folding
- Protein Structure, Secondary
- Recombinant Fusion Proteins