Energetic components of the allosteric machinery in hemoglobin measured by hydrogen exchange.

doi:10.1006/jmbi.1998.2278

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Article

Energetic components of the allosteric machinery in hemoglobin measured by hydrogen exchange.

Journal of molecular biology - 18 Dec 1998

Englander J J, Louie G, McKinnie R E, Englander S W

Abstract excerpt

A hydrogen exchange (HX) functional labeling method was used to study allosterically active segments in human hemoglobin (Hb) at the alpha-chain N terminus and the beta-chain C terminus. Allosterically important interactions that contact these segments were removed one or more at a time by mutati...

Topics

Allosteric Regulation
Arginine
Chlorides
Cross-Linking Reagents
Hemoglobins
Histidine
Humans
Hydrogen
Isotope Labeling
Mutation
Phosphates
Protein Conformation
Tritium

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