Article
Polymerase chain reaction analysis of allele frequency and loss at the Harvey ras locus in myeloid malignancies.
Leukemia - 1 Feb 1993
Ardern J C, Saunders M J, Hyde K, Lawson R, Yin J A, Lucas G S
Abstract excerpt
The hypothesis that 'rare' variable number tandem repeat (VNTR) alleles of the Harvey ras (Ha-ras) locus are an inherited predisposing factor in myeloid malignancies has been evaluated. We describe an application of the polymerase chain reaction (PCR) which amplifies the VNTR region at the Ha-ras locus and offers a number of advantages over conventional Southern analysis. Ha-ras VNTR genotypes were assigned to 57...
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