Unique allelic restriction fragments of the human Ha-ras locus in leukocyte and tumour DNAs of cancer patients.

doi:10.1038/313369a0

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Article

Unique allelic restriction fragments of the human Ha-ras locus in leukocyte and tumour DNAs of cancer patients.

Nature - 1 Jan 2000

Krontiris T G, DiMartino N A, Colb M, Parkinson D R

Abstract excerpt

White blood cell DNA from cancer patients and DNA from tumours and tumour-derived cell lines frequently demonstrated allelic restriction fragments of the Harvey ras oncogene locus not found in the unaffected population. The presence of such unusual alleles may be linked to susceptibility to cancer.

Topics

Alleles
Cell Line
Chromosome Mapping
DNA
DNA Restriction Enzymes
DNA, Neoplasm
Deoxyribonuclease BamHI
Deoxyribonuclease HpaII
Female
Genotype
Humans
Leukocytes
Neoplasms
Polymorphism, Genetic

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