Article
Stepwise neoplastic transformation of a telomerase immortalized fibroblast cell line.
Cancer research - 15 Dec 2005
Zongaro Samantha, de Stanchina Elisa, Colombo Tina, D'Incalci Maurizio, Giulotto Elena, Mondello Chiara
Abstract excerpt
We have described recently a human fibroblast cell line immortalized through ectopic telomerase expression (cen3tel), in which the extension of the life span was associated with the appearance of chromosomal aberrations and with the ability to grow in the absence of solid support. As reported in this article, on further propagation in culture, cen3tel cells became neoplastically transformed, being able to form...
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