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Article

The involvement of the intestinal microflora in the expansion of CD4+ T cells with a naive phenotype in the periphery.

Developmental immunology - 1 Jan 1992

Dobber R, Hertogh-Huijbregts A, Rozing J, Bottomly K, Nagelkerken L

Abstract excerpt

It is well known that immune reactivity declines with age. Recently, we demonstrated that the age-related decrease in IL-2 production by CD4+ T cells was accompanied by an increased production of IL-4 and interferon-gamma (IFN-gamma). This age-related shift in the profile of lymphokine production was related to phenotypic changes within the CD4+ T-cell subset, that is, a decrease in the percentage of CD45RB++...

Topics

Animals
Antigens, CD
CD4 Antigens
Female
Germ-Free Life
Histocompatibility Antigens
Intestines
Leukocyte Common Antigens
Male
Mice
Mice, Inbred CBA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Receptors, Lymphocyte Homing

Specific Pathogen-Free Organisms

Spleen

T-Lymphocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 1386544
DOI: 10.1155/1992/57057
PMCID: PMC2275855

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1386544-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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