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Article

Naïve T Cells in the Elderly

1 May 2006

Abstract excerpt

One of the most striking changes in the primary lymphoid organs during human aging is the progressive involution of the thymus. As a consequence, the rate of naïve T cell output dramatically declines with age and the peripheral T cell pool shrinks. These changes lead to increased incidence of severe infections and decreased protective effect of vaccinations in the elderly. Little is, however, known of the...

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PMID: 16803980
DOI: 10.1196/annals.1354.018

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