Age-related increase in the fraction of CD27-CD4+ T cells and IL-4 production as a feature of CD4+ T cell differentiation in vivo.

doi:10.1111/j.1365-2249.1994.tb06061.x

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Article

Age-related increase in the fraction of CD27-CD4+ T cells and IL-4 production as a feature of CD4+ T cell differentiation in vivo.

Clinical and experimental immunology - 1 Jun 1994

Nijhuis E W, Remarque E J, Hinloopen B, Van der Pouw-Kraan T, Van Lier R A, Ligthart G J, Nagelkerken L

Abstract excerpt

The influence of ageing on phenotype and function of CD4+ T cells was studied by comparing young (19-28 years of age) and aged (75-84 years of age) donors that were selected using the SENIEUR protocol to exclude underlying disease. An age-related increase was observed in the relative number of me...

Topics

Adult
Aged
Aged, 80 and over
Aging
CD4-Positive T-Lymphocytes
Cell Differentiation
Humans
Immunologic Memory
Interleukin-2
Interleukin-4
Leukocyte Common Antigens
Lymphocyte Activation
Phenotype
T-Lymphocyte Subsets
Tumor Necrosis Factor Receptor Superfamily, Member 7

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Identifiers

PMID: 7911751
DOI: 10.1111/j.1365-2249.1994.tb06061.x
PMCID: PMC1534577

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7911751-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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