Article
Age-related increase in the fraction of CD27-CD4+ T cells and IL-4 production as a feature of CD4+ T cell differentiation in vivo.
Clinical and experimental immunology - 1 Jun 1994
Nijhuis E W, Remarque E J, Hinloopen B, Van der Pouw-Kraan T, Van Lier R A, Ligthart G J, Nagelkerken L
Abstract excerpt
The influence of ageing on phenotype and function of CD4+ T cells was studied by comparing young (19-28 years of age) and aged (75-84 years of age) donors that were selected using the SENIEUR protocol to exclude underlying disease. An age-related increase was observed in the relative number of memory cells, not only on the basis of a decreased CD45RA and increased CD45RO expression, but also on the basis of a...
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