Article
Identification of two major types of age-associated CD8 clonal expansions with highly divergent properties.
Proceedings of the National Academy of Sciences of the United States of America - 2 Sept 2008
Clambey Eric T, White Janice, Kappler John W, Marrack Philippa
Abstract excerpt
CD8 memory T cells are tightly regulated in young, healthy individuals but are often perturbed in aged animals by the appearance of large CD8 T cell clones. These clones are associated with impaired immunity in the aged. The molecular basis of this phenomenon remains unclear. Here, it is shown that the issue is confused by the fact that the clones are heterogeneous. Some clones bear high, and others, low levels...
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