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Article

Localization of gamma/delta T cells to the intestinal epithelium is independent of normal microbial colonization.

The Journal of experimental medicine - 1 Jul 1990

Bandeira A, Mota-Santos T, Itohara S, Degermann S, Heusser C, Tonegawa S, Coutinho A

Abstract excerpt

Using monoclonal antibodies identifying all gamma/delta and alpha/beta T cell receptors in cytofluorometric analysis, we have compared the composition of intestinal intraepithelial lymphocytes (i-IEL) in euthymic and athymic germ-free (GF) and conventional (SPF) mice. The results show a marked influence of microbial colonization in the numbers of single-positive (CD4+ or CD8+) alpha/beta i-IEL, but little effect...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 2141628
DOI: 10.1084/jem.172.1.239
PMCID: PMC2188170

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Localization of gamma/delta T cells to the intestinal epithelium is independent of normal microbial colonization.PMID 2141628Read ↗

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Origin, trafficking, and intraepithelial fate of gut-tropic T cells.Semantic proximity Read ↗

Constitutive biological activity of thymus-independent TCR-alpha-beta+ intestinal intraepithelial lymphocytes in TCR-alpha-/- gene disruption mice.Semantic proximity Read ↗

Thymus-independent development and negative selection of T cells expressing T cell receptor alpha/beta in the intestinal epithelium: evidence for distinct circulation patterns of gut- and thymus-derived T lymphocytes.Semantic proximity Read ↗

T-cell alpha beta + and gamma delta + deficient mice display abnormal but distinct phenotypes toward a natural, widespread infection of the intestinal epithelium.Semantic proximity Read ↗

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The involvement of the intestinal microflora in the expansion of CD4+ T cells with a naive phenotype in the periphery.Semantic proximity Read ↗

Gut cryptopatches: direct evidence of extrathymic anatomical sites for intestinal T lymphopoiesis.Semantic proximity Read ↗

Protection of the intestinal mucosa by intraepithelial gamma delta T cells.Semantic proximity Read ↗

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