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Article

Impaired regulatory T cell function in germ-free mice.

European journal of immunology - 1 Sept 2006

Ostman Sofia, Rask Carola, Wold Agnes E, Hultkrantz Susanne, Telemo Esbjörn

Abstract excerpt

Regulatory T cells (Treg) are crucial for the maintenance of tolerance to auto-antigens and harmless exogenous antigens. Here, we studied the role of the commensal microbiota for the development and function of Treg. CD4+CD25+ T cells were obtained from peripheral lymph nodes (PLN) and mesenteric lymph nodes (MLN) of germ-free (GF) and conventional (conv) NMRI mice and tested for phenotype and functional...

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Source

Identifiers

PMID: 16897813
DOI: 10.1002/eji.200535244

Genes

MLN
PLN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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