Article
Dual TCR Expression Biases Lung Inflammation in DO11.10 Transgenic Mice and Promotes Neutrophilia via Microbiota-Induced Th17 Differentiation
23 Aug 2011
Abstract excerpt
A commonly used mouse model of asthma is based on i.p. sensitization to OVA together with aluminum hydroxide (alum). In wild-type BALB/c mice, subsequent aerosol challenge using this protein generates an eosinophilic inflammation associated with Th2 cytokine expression. By constrast, in DO11.10 mice, which are transgenic for an OVA-specific TCR, the same treatment fails to induce eosinophilia, but instead...
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