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Article

T cell genetic background determines default T helper phenotype development in vitro.

The Journal of experimental medicine - 1 Feb 1995

Hsieh C S, Macatonia S E, O'Garra A, Murphy K M

Abstract excerpt

A host's ability to resist certain pathogens such as Leishmania major can depend upon the phenotype of T helper (Th) subset that develops. Different murine genetic backgrounds are known to significantly alter the direction of Th subset development, although the cellular basis of this influence is poorly understood. To examine the basis of this effect we used an in vitro alpha/beta-T cell receptor (TCR) transgenic...

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Identifiers

PMID: 7836924
DOI: 10.1084/jem.181.2.713
PMCID: PMC2191880

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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