T cell genetic background determines default T helper phenotype development in vitro.

doi:10.1084/jem.181.2.713

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Article

T cell genetic background determines default T helper phenotype development in vitro.

The Journal of experimental medicine - 1 Feb 1995

Hsieh C S, Macatonia S E, O'Garra A, Murphy K M

Abstract excerpt

A host's ability to resist certain pathogens such as Leishmania major can depend upon the phenotype of T helper (Th) subset that develops. Different murine genetic backgrounds are known to significantly alter the direction of Th subset development, although the cellular basis of this influence is...

Topics

Animals
Antibody-Producing Cells
Cell Differentiation
Cells, Cultured
Leishmania major
Macrophages
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Transgenic
Nitric Oxide
Phenotype
Receptors, Antigen, T-Cell, alpha-beta
Th1 Cells
Th2 Cells

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