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Induction of Th2 type immunity in a mouse system reveals a novel immunoregulatory role of basophils

28 Nov 2006

Abstract excerpt

While production of cytokines such as IL-12 by activated dendritic cells supports development of Th1 type immunity, a source of early IL-4 that is responsible for Th2 immunity is not well understood. We now show that coculture of basophils could promote a robust Th2 differentiation upon stimulation of naive CD4 T cells primarily via IL-4. Th2 promotion by basophils was also observed even when naive CD4 T cells...

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PMID: 17132717
DOI: 10.1182/blood-2006-07-037739

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