Article
Phenotype-specific "tissue" transglutaminase regulation in human neuroblastoma cells in response to retinoic acid: correlation with cell death by apoptosis.
International journal of cancer - 9 Sept 1992
Piacentini M, Annicchiarico-Petruzzelli M, Oliverio S, Piredda L, Biedler J L, Melino E
Abstract excerpt
Neuroblastomas in culture are characterized by the presence of 2 morphologically and biochemically distinct phenotypes (i.e., neural "N-type" and flat substrate-adherent "S-type") which undergo transdifferentiation. Human neuroblastoma SK-N-BE(2) cells differentiate toward a neural phenotype upon retinoic acid (RA) treatment. However, we recently showed that, during the RA treatment, a subset of SK-N-BE(2) cells...
Topics
- Cell Death
- Cell Differentiation
- Cell Division
- Humans
- Neuroblastoma
- Phenotype
- RNA, Messenger
- RNA, Neoplasm
- Staining and Labeling
- Transglutaminases
- Tretinoin