Article
Tissue transglutaminase and apoptosis: sense and antisense transfection studies with human neuroblastoma cells.
Molecular and cellular biology - 1 Oct 1994
Melino G, Annicchiarico-Petruzzelli M, Piredda L, Candi E, Gentile V, Davies P J, Piacentini M
Abstract excerpt
In this report, we show that the overexpression of tissue transglutaminase (tTG) in the human neuroblastoma cell line SK-N-BE(2) renders these neural crest-derived cells highly susceptible to death by apoptosis. Cells transfected with a full-length tTG cDNA, under the control of a constitutive pr...
Topics
- Apoptosis
- Cell Adhesion Molecules, Neuronal
- Cloning, Molecular
- Gene Expression
- Genetic Variation
- Humans
- Neural Crest
- Neuroblastoma
- Protein Processing, Post-Translational
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-bcl-2
- RNA, Antisense
- Recombinant Proteins