Article
Tissue transglutaminase and apoptosis: sense and antisense transfection studies with human neuroblastoma cells.
Molecular and cellular biology - 1 Oct 1994
Melino G, Annicchiarico-Petruzzelli M, Piredda L, Candi E, Gentile V, Davies P J, Piacentini M
Abstract excerpt
In this report, we show that the overexpression of tissue transglutaminase (tTG) in the human neuroblastoma cell line SK-N-BE(2) renders these neural crest-derived cells highly susceptible to death by apoptosis. Cells transfected with a full-length tTG cDNA, under the control of a constitutive promoter, show a drastic reduction in proliferative capacity paralleled by a large increase in cell death rate. The dying...
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