Article
Tissue transglutaminase-dependent posttranslational modification of the retinoblastoma gene product in promonocytic cells undergoing apoptosis.
Molecular and cellular biology - 1 Oct 1997
Oliverio S, Amendola A, Di Sano F, Farrace M G, Fesus L, Nemes Z, Piredda L, Spinedi A, Piacentini M
Abstract excerpt
The retinoblastoma gene product (pRB) plays an important role in controlling both cell release from the G1 phase and apoptosis. We show here that in the early phases of apoptosis, pRB is posttranslationally modified by a tissue transglutaminase (tTG)-catalyzed reaction. In fact, by employing a novel haptenized lysis synthetic substrate which allows the isolation of glutaminyl-tTG substrates in vivo, we identified...
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