Article
Tissue transglutaminase-dependent posttranslational modification of the retinoblastoma gene product in promonocytic cells undergoing apoptosis.
Molecular and cellular biology - 1 Oct 1997
Oliverio S, Amendola A, Di Sano F, Farrace M G, Fesus L, Nemes Z, Piredda L, Spinedi A, Piacentini M
Abstract excerpt
The retinoblastoma gene product (pRB) plays an important role in controlling both cell release from the G1 phase and apoptosis. We show here that in the early phases of apoptosis, pRB is posttranslationally modified by a tissue transglutaminase (tTG)-catalyzed reaction. In fact, by employing a no...
Topics
- Apoptosis
- Blood
- Cadaverine
- Carrier Proteins
- Cell Cycle Proteins
- Cell Line
- Ceramides
- DNA-Binding Proteins
- E2F Transcription Factors
- E2F1 Transcription Factor
- Enzyme Inhibitors
- GTP Phosphohydrolases
- GTP-Binding Proteins
- Humans