Bi-modal differentiation pattern in a new human neuroblastoma cell line in vitro.

doi:10.1002/ijc.2910510214

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Article

Bi-modal differentiation pattern in a new human neuroblastoma cell line in vitro.

International journal of cancer - 8 May 1992

Matsushima H, Bogenmann E

Abstract excerpt

We have isolated a human neuroblastoma (NB) cell line, HTLA230, from the bone-marrow aspirate of a patient with stage-IV disease. Subcutaneous tumors after inoculation of HTLA230 cells into nude mice were composed of primitive neuroblasts which rarely contained neuro-secretory granules. Cytogenetic studies of the cell line demonstrated 2 distinct populations of cells with common chromosomal markers. Stable...

Topics

Animals
Cell Differentiation
Drug Resistance
Gene Amplification
Gene Expression Regulation, Neoplastic
Genes, myc
Humans
Infant
Male
Mice
Mice, Nude
Neuroblastoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nucleic Acid Hybridization

Phenotype

RNA, Messenger

RNA, Neoplasm

Tretinoin

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 1568793
DOI: 10.1002/ijc.2910510214

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1568793-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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