Article
TOP2B Is Required to Maintain the Adrenergic Neural Phenotype and for ATRA-Induced Differentiation of SH-SY5Y Neuroblastoma Cells.
Molecular neurobiology - 1 Oct 2022
Khazeem Mushtaq M, Casement John W, Schlossmacher George, Kenneth Niall S, Sumbung Nielda K, Chan Janice Yuen Tung, McGow Jade F, Cowell Ian G, Austin Caroline A
Abstract excerpt
The neuroblastoma cell line SH-SY5Y is widely used to study retinoic acid (RA)-induced gene expression and differentiation and as a tool to study neurodegenerative disorders. SH-SY5Y cells predominantly exhibit adrenergic neuronal properties, but they can also exist in an epigenetically interconvertible alternative state with more mesenchymal characteristics; as a result, these cells can be used to study gene...
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