Article
A comparative analysis of neuroblastic and substrate-adherent human neuroblastoma cell lines.
Journal of pediatric surgery - 1 Feb 1996
La Quaglia M P, Manchester K M
Abstract excerpt
In human neuroblastoma cell cultures, two phenotypes with differing biological properties have been described: neuroblastic (N) and substrate-adherent (Schwannian or S). In nude mice, N cells are rapidly growing, clonigenic in soft agar, and tumorigenic, whereas S cells are not. The difference in malignant properties between these two cell types and their ability to interconvert in vitro may have clinical...
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