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Article

Distinct mechanisms of cell cycle arrest control the decision between differentiation and senescence in human neuroblastoma cells

31 Jul 2001

Abstract excerpt

Retinoic acid (RA) induces cell cycle arrest and differentiation of human neuroblastoma (NB) cells. Typically, NB cells differentiate along the neuronal lineage, but quiescent, "flat" cell types frequently have been described after treatment with differentiating agents. Two indistinguishable subclones of the cell line SK-N-SH, SK-N-SH-N (SH-N) and SK-N-SH-F (SH-F), display dramatically different responses to RA....

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PMID: 11481496
DOI: 10.1073/pnas.161288698

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