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Article

Regulation of ras p21 by GTPase activating proteins.

Cold Spring Harbor symposia on quantitative biology - 1 Jan 1991

McCormick F, Martin G A, Clark R, Bollag G, Polakis P

Abstract excerpt

We propose a model for dual effector functions of the known ras GAPs p120-GAP and NF1-GAP. This model is consistent with known biological and biochemical effects of GAPs in mammalian cells, but it is clearly not a proven hypothesis, and several difficulties remain in making this model convincing. One is the apparent difference between mammalian cells and yeasts, in which GAPs do not have a demonstrable effector...

Topics

Animals
Cell Transformation, Neoplastic
GTPase-Activating Proteins
Humans
Models, Biological
Mutation
Neurofibromin 1
Phosphoproteins
Platelet-Derived Growth Factor
Proteins
Proto-Oncogene Proteins p21(ras)

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Cell Surface

Receptors, Platelet-Derived Growth Factor

Signal Transduction

ras GTPase-Activating Proteins

Source

Identifiers

PMID: 1668082
DOI: 10.1101/sqb.1991.056.01.029

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1668082-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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