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Article

PDGF beta-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex.

Cell - 6 Apr 1990

Kaplan D R, Morrison D K, Wong G, McCormick F, Williams L T

Abstract excerpt

Platelet-derived growth factor (PDGF) stimulated the tyrosine phosphorylation of the GTPase activating protein (GAP) in 3T3 cells and in CHO cells expressing wild-type PDGF receptors, but not in several CHO cell lines expressing mutant receptors defective in transmitting mitogenic signals. Following PDGF treatment of cells, GAP physically associated with the PDGF receptor and with Raf-1, phospholipase c-gamma,...

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Identifiers

PMID: 2156626
DOI: 10.1016/0092-8674(90)90220-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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