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Article

Suppression of c-ras transformation by GTPase-activating protein.

Nature - 23 Aug 1990

Zhang K, DeClue J E, Vass W C, Papageorge A G, McCormick F, Lowy D R

Abstract excerpt

The ras genes are required for normal cell growth and mediate transformation by oncogenes encoding protein tyrosine kinases. Normal ras can transform cells in vitro and in vivo, but mutationally activated ras does so much more efficiently, and highly transforming mutant versions of ras have been isolated from a variety of human and animal tumours. The ras genes encode membrane-associated, guanine...

Topics

Animals
Cell Line
Cell Transformation, Neoplastic
GTPase-Activating Proteins
Gene Expression Regulation
Genes, ras
Mice
Mutation
Plasmids
Proteins
Restriction Mapping
Suppression, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transfection

ras GTPase-Activating Proteins

Source

Identifiers

PMID: 2201922
DOI: 10.1038/346754a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2201922-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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