Article
SH3 domains specifically regulate kinase activity of expressed Src family proteins.
The Journal of biological chemistry - 6 Jan 1995
Abrams C S, Zhao W
Abstract excerpt
The Src homology 2 (SH2) and Src homology 3 (SH3) domain are approximately 50% conserved in various Src family kinase members. Several lines of evidence suggest that in Src these domains are sequence motifs that direct substrate recognition, regulate kinase activity, or control subcellular locali...
Topics
- 3T3 Cells
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Line, Transformed
- DNA Primers
- Humans
- Mice
- Molecular Sequence Data
- Mutation
- Phosphorylation
- Protein-Tyrosine Kinases
- Proto-Oncogene Proteins pp60(c-src)
- Recombinant Fusion Proteins
- Sequence Deletion
- Substrate Specificity