Article
c-Src signaling induced by the adapters Sin and Cas is mediated by Rap1 GTPase.
Molecular and cellular biology - 1 Oct 2000
Xing L, Ge C, Zeltser R, Maskevitch G, Mayer B J, Alexandropoulos K
Abstract excerpt
Oncogenic Src proteins have been extensively studied to gain insight into the signaling mechanisms of Src. To better understand signaling through wild-type Src, we used an approach that involves activation of Src signaling through the binding of physiologic ligands to the Src SH3 domain. To this end, we used full-length and truncated versions of the multiadapter molecules Cas and Sin to activate c-Src, and we...
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