Biological and biochemical activity of v-Crk chimeras containing the SH2/SH3 regions of phosphatidylinositol-specific phospholipase C-gamma and Src.

doi:10.1128/JVI.66.1.115-121.1992

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Article

Biological and biochemical activity of v-Crk chimeras containing the SH2/SH3 regions of phosphatidylinositol-specific phospholipase C-gamma and Src.

Journal of virology - 1 Jan 1992

Matsuda M, Reichman C T, Hanafusa H

Abstract excerpt

The chicken CT10 virus oncogene product, P47gag-crk, contains SH2/SH3 domains that have been identified as conserved domains among proteins involved in signal transduction. We studied the functional similarity of the SH2/SH3 domains by replacing those of v-Crk with those of phosphatidylinositol-s...

Topics

Animals
Base Sequence
Cell Transformation, Neoplastic
Cells, Cultured
Chick Embryo
Chimera
Cloning, Molecular
DNA, Viral
Electrophoresis, Polyacrylamide Gel
Molecular Sequence Data
Mutation
Oncogene Protein pp60(v-src)

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oncogene Protein v-crk

Phosphatidylinositols

Proto-Oncogene Proteins

Proto-Oncogene Proteins pp60(c-src)

Retroviridae Proteins

Substrate Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 1370084
DOI: 10.1128/JVI.66.1.115-121.1992
PMCID: PMC238266

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1370084-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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