Article
The SH2 domain is required for stable phosphorylation of p56lck at tyrosine 505, the negative regulatory site.
Molecular and cellular biology - 1 Nov 1993
Gervais F G, Chow L M, Lee J M, Branton P E, Veillette A
Abstract excerpt
The catalytic function of Src-related tyrosine protein kinases is repressed by phosphorylation of a conserved carboxy-terminal tyrosine residue. Recent studies suggest that this inhibitory event is not the result of autophosphorylation but that it is mediated by another cytoplasmic tyrosine protein kinase, termed p50csk. In this report, we have evaluated the processes regulating the extent of phosphorylation of...
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