Article
The SH2 domain is required for stable phosphorylation of p56lck at tyrosine 505, the negative regulatory site.
Molecular and cellular biology - 1 Nov 1993
Gervais F G, Chow L M, Lee J M, Branton P E, Veillette A
Abstract excerpt
The catalytic function of Src-related tyrosine protein kinases is repressed by phosphorylation of a conserved carboxy-terminal tyrosine residue. Recent studies suggest that this inhibitory event is not the result of autophosphorylation but that it is mediated by another cytoplasmic tyrosine prote...
Topics
- 3T3 Cells
- Amino Acid Sequence
- Animals
- Base Sequence
- Binding Sites
- Cloning, Molecular
- Conserved Sequence
- Gene Expression
- Genetic Variation
- Glutathione Transferase
- Kinetics
- Lymphocyte Specific Protein Tyrosine Kinase p56(lck)