Article
Site-directed mutagenesis of the SH2- and SH3-coding domains of c-src produces varied phenotypes, including oncogenic activation of p60c-src.
Molecular and cellular biology - 1 Apr 1990
Hirai H, Varmus H E
Abstract excerpt
The products of the viral and cellular src genes, p60v-src and p60c-src, appear to be composed of multiple functional domains. Highly conserved regions called src homology 2 and 3 (SH2 and SH3), comprising amino acid residues 88 to 250, are believed to modulate the protein-tyrosine kinase activity present in the carboxy-terminal halves of the src proteins. To explore the functions of these regions more fully, we...
Topics
- Animals
- Base Sequence
- Chick Embryo
- Fibroblasts
- Gene Expression Regulation, Neoplastic
- Molecular Sequence Data
- Multigene Family
- Mutation
- Oligonucleotide Probes
- Oncogene Protein pp60(v-src)
- Oncogenes