Article
Reactivation of host-dependent src kinase activity by co-expression with a heterologous tyrosine kinase.
Virology - 1 Jul 1993
Liebl E C, England L J, Martin G S
Abstract excerpt
XD4 is a host range deletion mutant (delta 77-225) of the v-src transforming gene. This mutant transforms chicken embryo fibroblasts (CEF) but not Rat-2 cells. It encodes a product (XD4-src) that is phosphorylated at tyrosine and active as a tyrosine kinase in CEF, but is neither phosphorylated at tyrosine nor active as a kinase in Rat-2 cells. We report here that the XD4-src kinase activity in Rat-2 cells can be...
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