Article
The SH3 domain of Src can downregulate its kinase activity in the absence of the SH2 domain-pY527 interaction.
Biochemical and biophysical research communications - 23 Aug 2002
Brábek Jan, Mojzita Dominik, Novotný Marian, Půta Frantisek, Folk Petr
Abstract excerpt
The contact between the SH2 domain and the C-terminal tail of c-Src inhibits its kinase activity via a complex network of interactions, including the SH3 domain. We examined the role of the SH3 domain in v-Src, where the C-terminal tail is mutated and unbound. We used the v-Src variants Prague C (PRC) and Schmidt-Ruppin A (SRA), which are of low and high kinase activities, respectively, to measure phosphorylation...
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