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Article

Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK.

Nature structural & molecular biology - 1 Jun 2007

Kobashigawa Yoshihiro, Sakai Mieko, Naito Masato, Yokochi Masashi, Kumeta Hiroyuki, Makino Yoshinori, Ogura Kenji, Tanaka Shinya, Inagaki Fuyuhiko

Abstract excerpt

CRKI (SH2-SH3) and CRKII (SH2-SH3-SH3) are splicing isoforms of the oncoprotein CRK that regulate transcription and cytoskeletal reorganization for cell growth and motility by linking tyrosine kinases to small G proteins. CRKI shows substantial transforming activity, whereas the activity of CRKII is low, and phosphorylated CRKII has no biological activity whatsoever. The molecular mechanisms underlying the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17515907
DOI: 10.1038/nsmb1241

Genes

CRK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK.PMID 17515907Read ↗

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