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Article

The position of heterologous epitopes inserted in hepatitis B virus core particles determines their immunogenicity

1 Jan 1992

Abstract excerpt

The nucleocapsid (HBcAg) of the hepatitis B virus (HBV) has been suggested as a carrier moiety for vaccine purposes. We investigated the influence of the position of the inserted epitope within hybrid HBcAg particles on antigenicity and immunogenicity. For this purpose, genes coding for neutralizing epitopes of the pre-S region of the HBV envelope proteins were inserted at the amino terminus, the amino terminus...

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Identifiers

PMID: 1370083
DOI: 10.1128/jvi.66.1.106-114.1992

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