Article
Distinct, cross-reactive epitope specificities of CD8 T cell responses are induced by natural hepatitis B surface antigen variants of different hepatitis B virus genotypes.
Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2006
Riedl Petra, Bertoletti Antonio, Lopes Ross, Lemonnier Francois, Reimann Jörg, Schirmbeck Reinhold
Abstract excerpt
We investigated the specific and cross-reactive CD8 T cell immunity to three natural variants (of different geno/serotype) of the small hepatitis B surface Ag (or S protein). The D(d)-binding variants of the S(201-209) epitope showed different immunogenicity. The loss of the consensus C-terminal (P9) anchor abrogated its immunogenicity. In contrast, a conservative (serine vs asparagine) exchange at P7 primed...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.