Article
The Hepatitis B Virus Core Variants that Expose Foreign C-Terminal Insertions on the Outer Surface of Virus-Like Particles.
Molecular biotechnology - 1 Dec 2015
Dishlers Andris, Skrastina Dace, Renhofa Regina, Petrovskis Ivars, Ose Velta, Lieknina Ilva, Jansons Juris, Pumpens Paul, Sominskaya Irina
Abstract excerpt
The major immunodominant region (MIR) and N-terminus of the hepatitis B virus (HBV) core (HBc) protein were used to expose foreign insertions on the outer surface of HBc virus-like particles (VLPs). The additions to the HBc positively charged arginine-rich C-terminal (CT) domain are usually not exposed on the VLP surface. Here, we constructed a set of recombinant HBcG vectors in which CT arginine stretches were...
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