Article
Different immunogenicity of H-2 Kb-restricted epitopes in natural variants of the hepatitis B surface antigen.
European journal of immunology - 1 Sept 2003
Schirmbeck Reinhold, Böhm Waltraud, Fissolo Nicolas, Melber Karl, Reimann Jörg
Abstract excerpt
The small hepatitis B surface antigen (HBsAg) of hepatitis B virus (HBV) has limited variability, but some serotypes and genotypes have been defined. Although no biological or pathogenetic differences could be traced to HBV serotypes, the clinical picture, response to treatment and long-term prognosis of HBV infection may vary with the HBV genotype, possibly due to differences in specific T cell recognition of...
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