Article
Two distinct segments of the hepatitis B virus surface antigen contribute synergistically to its association with the viral core particles.
Journal of molecular biology - 26 Feb 1999
Tan W S, Dyson M R, Murray K
Abstract excerpt
The long surface antigen polypeptide (L-HBsAg) of hepatitis B virus (HBV) is believed to mediate contact between the virus envelope and nucleocapsid protein (HBcAg). The N and C termini of L-HBsAg were shortened progressively in order to define the minimum contiguous sequence of amino acids that contains the residues necessary for association with HBcAg. The resulting mutants were expressed in rabbit reticulocyte...
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