Article
Benzquinamide inhibits P-glycoprotein mediated drug efflux and potentiates anticancer agent cytotoxicity in multidrug resistant cells.
Oncology research - 1 Jan 1992
Mazzanti R, Croop J M, Gatmaitan Z, Budding M, Steiglitz K, Arceci R, Arias I M
Abstract excerpt
We have previously shown that efflux of cytotoxic drugs from multidrug resistant (MDR) cell lines can be quantitated at the single cell level using a sensitive fluorescence microscopy technique. Based on the structure of compounds which inhibited the efflux of Rhodamine-123 (Rho-123) using this m...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Affinity Labels
- Animals
- Antineoplastic Agents
- Cell Survival
- Cricetinae
- Drug Resistance
- Drug Synergism
- Humans
- Membrane Glycoproteins
- Mice
- Microscopy, Fluorescence
- Neoplasm Proteins
- Phenotype
- Protein Binding
- Quinolizines
- Rhodamine 123
- Rhodamines