Article
Swelling-activated chloride channels in multidrug-sensitive and -resistant cells.
The Journal of general physiology - 1 Dec 1994
Ehring G R, Osipchuk Y V, Cahalan M D
Abstract excerpt
Resistance to chemotherapeutic agents in neoplastic cells is often mediated by expression of P-glycoprotein, which functions as a drug-efflux pump for a broad range of substrates. We have used a combination of patch clamp and video-imaging techniques to examine the expression and drug-efflux func...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- Cell Membrane
- Chloride Channels
- Clone Cells
- Drug Resistance, Multiple
- Fibroblasts
- Flow Cytometry
- Indicators and Reagents
- Mice
- Microscopy, Confocal
- Microscopy, Fluorescence
- Multiple Myeloma
- Patch-Clamp Techniques
- Phenotype
- Tumor Cells, Cultured