Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Enhancement of doxorubicin activity in multidrug-resistant cells by mefloquine.

Methods and findings in experimental and clinical pharmacology - 1 Jun 2000

Fujita R, Ishikawa M, Takayanagi M, Takayanagi Y, Sasaki K

Abstract excerpt

We studied the effect of the antimalarial drug mefloquine on the resistance of K562 cells to doxorubicin. Mefloquine synergistically potentiated the cytotoxicity of doxorubicin for doxorubicin-resistant K562 cells (K562/DXR) at a concentration of 0.5-3 microM, but had hardly any synergistic effect in the parental cell line (K562) at the same concentration. Mefloquine was more potent than verapamil, a known...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Affinity Labels
Share to Antibiotics, Antineoplastic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Azides

Share to Calcium Channel Blockers

Share to Coloring Agents

Share to Mefloquine

Share to Rhodamine 123

Share to Verapamil

Source

Identifiers

PMID: 11031728
DOI: 10.1358/mf.2000.22.5.796646

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enhancement of doxorubicin activity in multidrug-resistant cells by mefloquine.PMID 11031728Read ↗

Differential effects of verapamil and quinine on the reversal of doxorubicin resistance in a human leukemia cell line.Semantic proximity Read ↗

Dexrazoxane significantly impairs the induction of doxorubicin resistance in the human leukaemia line, K562.Semantic proximity Read ↗

Detection of human leukemia cells with multidrug-resistance phenotype using multilabeling with fluorescent dyes.Semantic proximity Read ↗

Mitotracker Green Is a P-Glycoprotein SubstrateSemantic proximity Read ↗

Relationship between expression of P-glycoprotein and efficacy of trifluoperazine in multidrug-resistant cells.Semantic proximity Read ↗

Flow cytometry evaluation of the multidrug-resistant phenotype with functional tests involving uptake of daunorubicin, Hoechst 33342, or rhodamine 123: a comparative study.Semantic proximity Read ↗

Benzquinamide inhibits P-glycoprotein mediated drug efflux and potentiates anticancer agent cytotoxicity in multidrug resistant cells.Semantic proximity Read ↗

Immunosuppressants FK506 and rapamycin function as reversal agents of the multidrug resistance phenotype.Semantic proximity Read ↗

Multidrug resistance phenotype evaluation by immunofluorescence and functional tests: comparison of two monoclonal antibodies and three fluorescent dyes in three cells lines.Semantic proximity Read ↗

Comparison of the efficacy of a phenothiazine and a bisquinaldinium calmodulin antagonist against multidrug-resistant P388 cell lines.Semantic proximity Read ↗

Reversal of multidrug resistance in HL-60 cells by verapamil and liposome-encapsulated doxorubicin.Semantic proximity Read ↗

Relationship between therapeutic efficacy of doxorubicin-transferrin conjugate and expression of P-glycoprotein in chronic erythromyeloblastoid leukemia cells sensitive and resistant to doxorubicinSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.