Article
Staining with Hoechst 33342 and rhodamine 123: an attempt to detect multidrug resistant phenotype cells in leukemia.
Leukemia research - 1 Dec 1993
Lahmy S, Lautier D, Canitrot Y, Laurent G, Salmon J M
Abstract excerpt
Development of resistance is the major cause of failure in chemotherapeutic treatments. We have previously shown that the level of labeling with Hoechst 33342 and rhodamine 123 in established cell lines was decreased in cells with 'classic' MDR phenotype. This functional test was carried out usin...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Adult
- Aged
- Antigens, CD
- Benzimidazoles
- Carrier Proteins
- Drug Resistance
- Female
- Flow Cytometry
- Fluorescent Dyes
- Humans
- Leukemia, Lymphocytic, Chronic, B-Cell
- Lymphocytes
- Male
- Membrane Glycoproteins
- Middle Aged
- Phenotype
- Rhodamine 123