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Article

Methanethiosulfonate derivatives of rhodamine and verapamil activate human P-glycoprotein at different sites.

The Journal of biological chemistry - 12 Dec 2003

Loo Tip W, Bartlett M Claire, Clarke David M

Abstract excerpt

The human multidrug resistance P-glycoprotein (P-gp, ABCB1) actively extrudes a broad range of potentially cytotoxic compounds out of the cell. Key steps in understanding the transport process are binding of drug substrates in the transmembrane domains, initiation of ATPase activity, and subsequent drug efflux. We used cysteine-scanning mutagenesis of the transmembrane segment residues and reaction with the...

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Identifiers

PMID: 14522974
DOI: 10.1074/jbc.M310448200

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Methanethiosulfonate derivatives of rhodamine and verapamil activate human P-glycoprotein at different sites.PMID 14522974Read ↗

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Identification of Residues within the Drug-binding Domain of the Human Multidrug Resistance P-glycoprotein by Cysteine-scanning Mutagenesis and Reaction with DibromobimaneSemantic proximity Read ↗

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