Article
Multidrug resistance activity in human lymphocytes.
Human immunology - 1 Oct 1991
Coon J S, Wang Y Z, Bines S D, Markham P N, Chong A S, Gebel H M
Abstract excerpt
The multidrug resistance gene (mdr1) is a member of the recently described ATP binding cassette (ABC) superfamily of transporters. Family members include: (1) the cystic fibrosis transmembrane conductance regulator gene; (2) the hlyB gene of bacteria, and (3) the histocompatibility antigen modifier (HAM) gene. The level of expression of mdr1 correlates with multidrug resistance (MDR), the ability of cells to...
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