Article
A 5-year follow-up study of 3 polymorphisms in the human glucocorticoid receptor gene in relation to obesity, hypertension, and diabetes.
Journal of the cardiometabolic syndrome - 1 Jan 2008
Rosmond Roland, Holm Göran
Abstract excerpt
Glucocorticoid receptors (GRs) are cytoplasmaticreceptors regulating the expression of cortisol and bind to specific sites on chromatin. The glucocorticoid receptor gene (GRL) is located on chromosome 5q31 and encodes for either a 777-amino acid (GRalpha) or a 742-amino acid (GRbeta) polypeptide. The objective of the current study was to examine the prospective association of 3 polymorphisms-a Tth111I restriction...
Topics
- Alleles
- Blotting, Southern
- DNA
- Diabetes Mellitus
- Follow-Up Studies
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Humans
- Hypertension
- Male
- Middle Aged
- Obesity
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Prognosis
- Receptors, Glucocorticoid
- Retrospective Studies