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Article

Differential modulation of cellular and viral promoters by p73 and p53.

International journal of oncology - 1 Feb 2001

Deb D, Lanyi A, Scian M, Keiger J, Brown D R, Le Roith D, Deb S P, Deb S

Abstract excerpt

p73 has been shown to transcriptionally activate genes positively responsive to wild-type p53. In order to undertake a comparative study of functions of p53 and p73 we have cloned the cDNA of p73 from MCF-7 cells. Adenovirus onco-protein E1A inhibits the transactivation by p73; a deletion mutant of E1A incapable of interacting with p300 and CREB-binding protein (CBP) fails to disrupt the transactivation....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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PMID: 11172610

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Differential modulation of cellular and viral promoters by p73 and p53.PMID 11172610Read ↗

p73 function is inhibited by tumor-derived p53 mutants in mammalian cells.Semantic proximity Read ↗

p21/CDKN1A mediates negative regulation of transcription by p53.Semantic proximity Read ↗

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Viral Oncoproteins Discriminate between p53 and the p53 Homolog p73Semantic proximity Read ↗

Autoinhibitory regulation of p73 by Delta Np73 to modulate cell survival and death through a p73-specific target element within the Delta Np73 promoter.Semantic proximity Read ↗

DNA damage induces transcriptional activation of p73 by removing C-EBPalpha repression on E2F1.Semantic proximity Read ↗

Comparative Analysis of P73 and P53 Regulation and Effector FunctionsSemantic proximity Read ↗

The N-Terminal Domain of p73 Interacts with the CH1 Domain of p300/CREB Binding Protein and Mediates Transcriptional Activation and ApoptosisSemantic proximity Read ↗

Modulation of cellular and viral promoters by mutant human p53 proteins found in tumor cells.Semantic proximity Read ↗

Inactivation of retinoblastoma (RB) tumor suppressor by oncogenic isoforms of the p53 family member p73.Semantic proximity Read ↗

Function of p73, not of p53, is inhibited by the physical interaction with RACK1 and its inhibitory effect is counteracted by pRB.Semantic proximity Read ↗

p73 or p53 directly regulates human p53 transcription to maintain cell cycle checkpoints.Semantic proximity Read ↗

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