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Article

Inhibition of mouse thymidylate synthase promoter activity by the wild-type p53 tumor suppressor protein.

Experimental cell research - 1 Aug 1997

Lee Y, Chen Y, Chang L S, Johnson L F

Abstract excerpt

The p53 tumor suppressor protein is an important negative regulator of the G1 to S transition in mammalian cells. We have investigated the effect of p53 on the expression of the mouse thymidylate synthase (TS) gene, which normally increases as cells enter S phase. A luciferase indicator gene that was driven by the wild-type or various modified forms of the TATA-less mouse TS promoter was transiently cotransfected...

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PMID: 9260894
DOI: 10.1006/excr.1997.3605

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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