A complex promoter element mediates transactivation of the human proliferating cell nuclear antigen promoter by the 243-residue adenovirus E1A oncoprotein.

doi:10.1128/mcb.13.3.1697-1707.1993

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Article

A complex promoter element mediates transactivation of the human proliferating cell nuclear antigen promoter by the 243-residue adenovirus E1A oncoprotein.

Molecular and cellular biology - 1 Mar 1993

Labrie C, Morris G F, Mathews M B

Abstract excerpt

The adenovirus E1A oncoproteins interfere with the normal regulation of cellular proliferation through interactions with cell cycle regulatory proteins. In view of the essential role of proliferating-cell nuclear antigen (PCNA) in DNA replication, we performed a mutational analysis of the minimal human PCNA promoter (nucleotides -87 to +62) to define sequence elements which mediate transactivation by the...

Topics

Adenovirus E1A Proteins
Antigens, Neoplasm
Base Sequence
Binding Sites
Consensus Sequence
DNA Mutational Analysis
Genetic Variation
HeLa Cells
Humans
Molecular Sequence Data
Mutagenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nuclear Proteins

Proliferating Cell Nuclear Antigen

Promoter Regions, Genetic

Sequence Alignment

Transcription, Genetic

Transcriptional Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 8095093
DOI: 10.1128/mcb.13.3.1697-1707.1993
PMCID: PMC359482

Genes

PCNA
CAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8095093-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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