Article
Activation of human immunodeficiency virus by herpes simplex virus.
The Journal of infectious diseases - 1 Sept 1992
Golden M P, Kim S, Hammer S M, Ladd E A, Schaffer P A, DeLuca N, Albrecht M A
Abstract excerpt
Heterologous viruses have been examined for their ability to accelerate the course of infection with the human immunodeficiency virus (HIV) type 1. In this study, ACH-2 cells persistently infected with HIV-1 exhibited augmented HIV-1 replication as a result of superinfection with herpes simplex virus (HSV) type 1. Using HSV-1 mutants with deletions in the genes encoding immediate-early proteins ICP0, ICP4, and...
Topics
- CD4-Positive T-Lymphocytes
- HIV-1
- Humans
- Kinetics
- Mutation
- RNA, Viral
- Simplexvirus
- Tumor Cells, Cultured
- Virus Activation
- Virus Replication